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目的：检测与分析p16基因表达产物在胃癌组织中的表达。探讨其与胃癌术后复发、转移及生存率的关系。方法：应用免疫组织化学方法检测84例胃癌标本中p16蛋白的表达。结果：84例中p16表达阳性率44．05％，转移淋巴结表达阳性率37．50％，明显低于正常组织及胃良性息肉。p16表达与组织学类型无关，与肿瘤浸润深度、临床分期及淋巴结转移有关。随访中发现，阴性表达者死亡率高、中位生存期短，转移复发率均高于阳性表达者(P＜0．01)。结论：p16蛋白异常表达在胃癌的发生发展过程中起重要作用。其可能成为临床评估肿瘤生物学行为及判断预后的标志之一。
Objective: To detect and analyze the expression of p16 gene expression product in gastric cancer. To explore its relationship with postoperative recurrence, metastasis and survival of gastric cancer. Methods: The expression of p16 protein in 84 gastric cancer specimens was detected by immunohistochemistry. Results: The positive rate of p16 expression was 44.05% in 84 cases, and the positive rate of metastatic lymph nodes was 37.50%. It was significantly lower than normal tissues and benign gastric polyps. P16 expression has nothing to do with histological type, but is related to depth of tumor invasion, clinical stage, and lymph node metastasis. During follow-up, negative expression showed a high mortality rate, a short median survival time, and a higher rate of metastasis and recurrence than those with positive expression (P<0.01). Conclusion: Abnormal expression of p16 protein plays an important role in the development of gastric cancer. It may be one of the markers for clinical evaluation of tumor biological behavior and prognosis.