氯喹及其对映体、去乙基氯喹与咯萘啶抗恶性疟原虫作用的体外试验研究

• 作 者: 符遂 A.Bjorkman B.Wahlin D.Ofori-Adjei O.Ericsson F.Sjoqvist
• 机 构: 中国预防医学科学院寄生虫病研究所,Karolinska Institute,Roslagstull Hospital,Sweden,Karolinska Institute,Huddinge Univ
• 出 处: 寄生虫学与寄生虫病杂志
• 发表日期: 1986年04期
• 关键词: 恶性疟原虫 体外试验 对映体 咯萘啶 乙基 抑制作用 抗疟药 伯氏疟原虫 小鼠实验 敏感株

用48小时的体外试验法比较了氯喹(CQ)及其两种对映体((+)-CQ,(-)-CQ),与氯喹的代谢产物去乙基氯喹(desethylchloroquine,DCQ)以及咯萘啶(pyronaridine,PY)对恶性疟原虫两个不同虫株的抑制作用. 上述5个化合物对CQ敏感株的抑制作用相似,对抗CQ株则DCQ的作用较差,而PY的作用显著优于其余4个化合物。

Chloroquine (CQ) and its two enantiomers ((+) - CQ and (-) - CQ) were compared with those of chloroquine, desethylchloroquine (DCQ), and 48 hours in vitro The inhibitory effect of pyronaridine (PY) on two different P. falciparum isolates.The inhibitory effects of these five compounds on CQ-sensitive isolates were similar, and the effect of DCQ against CQ strain was poorer, while the effect of PY was significantly better The remaining four compounds.