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糖尿病性骨质疏松并发骨折是一种较为严重的并发症。由于它的危害性较大,目前倍受重视。本文参考有关文献,从骨代谢变化、骨折发生的机理、预防等几方面综述近年来国内外研究的成果。 1 骨代谢及生物力学变化 1.1 糖尿病继发骨质疏松在骨代谢的研究中通常包括:骨密度(BMD)、反映骨形成的骨钙素(BGP)、反映骨吸收的24小时尿羟脯氨酸(HOP)及维生素D的代谢。骨再建的全过程包括活性骨形成,骨吸收和静止三个阶段。骨再建的速率与骨吸收的速率称为骨转换率。破骨细胞清除旧的矿物质,成骨细胞形成类骨质并进行矿化,因此骨代谢的过程往往能反映破骨细胞与成骨细胞的活动及骨基质、骨矿物质的
Diabetic osteoporosis complicated by fractures is a more serious complication. Due to its harmfulness, it has drawn great attention at present. This article refers to the literature, from the bone metabolism changes, the mechanism of fracture, prevention and other aspects reviewed in recent years, the results of domestic and foreign research. 1 BONE METABOLISM AND BIOMECHANICAL CHANGES 1.1 Secondary Diabetes Mellitus Osteoporosis usually includes in bone metabolism studies: bone mineral density (BMD), osteocalcin (BGP), which reflects bone formation, urinary hydroxyproline, which reflects bone resorption Acid (HOP) and vitamin D metabolism. The whole process of bone reconstruction, including active bone formation, bone resorption and resting three stages. The rate of bone remodeling and bone resorption is called the rate of bone turnover. Osteoclasts remove old minerals, osteoblasts form osteoid and mineralize, so the process of bone metabolism can often reflect the activity of osteoclasts and osteoblasts and bone matrix, bone mineral