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本文以低硒的克山病病区粮为基础饲料,研究了改变饲料中硒含量单一因素对[~3H]—亮氨酸参入胰蛋白质的速率和胰淀粉酶、糜蛋白酶活性的影响。结果发现硒缺乏可使大鼠胰腺组织蛋白质合成速度和胰淀粉酶、糜蛋白酶活性下降。结合低硒组大鼠胰腺GSH-Px活性下降,TBA值升高,推测由于缺硒大鼠胰腺中脂质过氧化物和其代谢分解产物丙二醛积蓄,导致生物膜的结构破坏、DNA和RNA的结构和含量改变、能量供给不足,以及对蛋白质、酶分子、氨基酸等的破坏而影响蛋白质合成体系的功能,使蛋白质合成速度下降。由于分泌蛋白质的合成下降,则出现胰腺外分泌功能障碍,胰淀粉酶、糜蛋白酶等活力降低。食物补硒后可以保护正常胰腺的结构和功能。
In this paper, we studied the effects of single factor of dietary selenium content on the rate of incorporation of [~ 3H] -leucine into pancreatic protein and the activity of pancreatic amylase and chymotrypsin in low-selenium Keshan disease ward. The results showed that selenium deficiency can make rat pancreatic tissue protein synthesis rate and pancreatic amylase, chymotrypsin activity decreased. Combined with low selenium group, GSH-Px activity in pancreas decreased and TBA value increased. It is speculated that the structure of biofilm was damaged due to the accumulation of lipid peroxides and malondialdehyde (MDA) in pancreas of selenium- RNA structure and content changes, lack of energy supply, as well as the destruction of proteins, enzymes, amino acids and other functions of the protein synthesis system, the protein synthesis rate decreased. Due to decreased synthesis of secreted proteins, pancreatic exocrine dysfunction occurs, pancreatic amylase, chymotrypsin and other vitality decreased. After selenium food can protect the structure and function of normal pancreas.