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细胞分裂活动较强时,核酸和去羟基核酸的合成和交换作用也较大。核酸的组成须有:(一)磷酸、(二)核醣,(三)一些嘧啶和嘌呤的衍生物,如:2-氨基6—羟基嘌呤(1),6—氨基嘌呤(2),2—羟基4—氨基5—甲基嘧啶(3),2—羟基4—氨基嘧啶(4),2,4—二羟基嘧啶(5)等。一种药物如能阻碍酸合成,即可能抑制肿瘤细胞。有几种药目前已应用于临床。抗叶酸代谢物叶酸(6)能帮助合成核酸和去羟基核酸交换所需要的嘧啶和嘌呤化合物。因此,抗叶酸代谢物被应用于肿瘤的治疗。与叶酸极相似的化合物如4
When cell division activity is strong, the synthesis and exchange of nucleic acid and dehydroxy nucleic acid are also larger. The composition of the nucleic acid must be: (a) phosphoric acid, (b) ribose, (c) some pyrimidine and purine derivatives such as 2-amino 6-hydroxy purine (1) Hydroxy 4-amino 5-methylpyrimidine (3), 2-hydroxy 4-aminopyrimidine (4), 2,4-dihydroxypyrimidine (5) and the like. A drug that inhibits acid synthesis can inhibit tumor cells. Several drugs have been used in clinical practice. The antifolate metabolite folic acid (6) helps to synthesize pyrimidine and purine compounds required for nucleic acid and dehydroxy nucleic acid exchange. Therefore, anti-folate metabolites are used in the treatment of tumors. Very similar to folic acid compounds such as 4