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目的探讨低分子肝素(low molecular weight heparin,LMWH)用于妊高征围手术期血栓预防治疗的临床效果及安全性。方法选择2009年3月—2010年12月住院妊高征孕妇,因疾病治疗效果不满意严重危及母婴安全终止妊娠或择期剖宫产113例。随机分为两组,观察组和对照组,观察组在常规治疗的基础上,于手术的前一天晚上,加用LMWH 5000 U,皮下注射,1次/d,连续5 d;通过临床症状、体征及B超等辅助检查,判断LMWH的对妊高征术后血栓形成的预防效果及对母儿的影响。结果观察组下肢深静脉血栓的发病率显著低于对照组(P<0.05),两组患者的出血倾向及围产儿结局无明显差异(P>0.05)。结论 LMWH用于妊高征围手术期血栓预防治疗效果明显;LMWH对母儿安全。
Objective To investigate the clinical effect and safety of low molecular weight heparin (LMWH) for the prevention and treatment of perioperative thromboembolism in pregnancy induced hypertension. Methods From March 2009 to December 2010, pregnant women with PIH were enrolled in this study. 113 cases of termination of pregnancy or elective cesarean section were endangered due to unsatisfactory treatment effect. The observation group was randomly divided into two groups: the observation group and the control group. On the basis of routine treatment, the observation group was given LMWH 5000 U on the night before the surgery, and injected subcutaneously once a day for 5 consecutive days. Signs and B ultrasound and other auxiliary examination to determine the prevention and treatment of LMWH on PIH thrombosis and the impact on the mother and child. Results The incidence of deep venous thrombosis in lower limbs in observation group was significantly lower than that in control group (P <0.05). There was no significant difference in hemorrhage tendency and perinatal outcome among two groups (P> 0.05). Conclusion LMWH is effective in preventing and treating thrombus during perioperative PIH. LMWH is safe for both mother and child.