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从九里香Murraya paniculata(L.)Jacks.茎皮中分离得到的糖蛋白成分给孕期12-16d的孕免ip10mg/kg或羊膜腔内注射3mg/胚胎,3-5d后获得明显的终止妊娠效果。同时给黄体酮1mg/kg连续6d不能对抗其抗孕作用。组织学检查蜕膜组织有变性、坏死,炎细胞浸润,血窦瘀血和出血等情况。本品对已孕和未孕小鼠离体子宫收缩无明显改变。在麻醉状态下,给孕兔iv10mg/kg时,5-6min后子宫呈张力增强性节律收缩。幼兔连续4d ip 20mg/kg不能对抗雌二醇和黄体酮所致的内膜增生反应。治疗量10mg/kg卵巢内妊娠黄体未见有特殊变化,指示终止妊娠不是抗黄体作用的结果。该糖蛋白既无雌激素样作用,又无抗HCG活性。在终止妊娠中可能是通过对蜕膜损害和导致PG释放而起作用。
Glycoprotein components isolated from the stem bark of Murraya paniculata (L.) Jacks. Gave intrauterine injections of 10 mg / kg ip or 3 mg / embryo during 12-16 days of gestation and significant termination of pregnancy after 3-5 days . At the same time to progesterone 1mg / kg 6d can not fight its anti-pregnancy effect. Histological examination of decidual tissue degeneration, necrosis, inflammatory cell infiltration, sinusoidal blood stasis and bleeding and so on. This product has been pregnant and non-pregnant mice without significant changes in uterine contractions. Under anesthesia, to pregnant rabbits iv10mg / kg, 5-6min after the uterus showed tension-enhancing rhythm contraction. Rabbits for 4 days ip 20mg / kg can not fight estradiol and progesterone induced endometrial hyperplasia. Treatment of 10mg / kg ovarian endometriosis no special changes in the body, indicating termination of pregnancy is not the result of anti-corpus luteum. The glycoprotein has neither estrogen-like effect nor anti-HCG activity. It may play a role in termination of pregnancy by damaging the decidua and causing PG release.