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目的探讨不孕症患者接受体外受精/卵细胞浆内单精子注射(IVF/ICSI)胚胎移植治疗临床妊娠后发生流产的可能相关因素。方法将2010年1月—2010年12月在本医院行IVF/ICSI治疗获得临床妊娠的512例患者,按妊娠结局分为流产组及分娩组;分析受精方式、年龄、病因及移植后12天血β-HCG等因素与流产率的关系。结果行IVF/ICSI助孕临床妊娠的患者中,流产率19.34%,抱婴儿回家率37.31%;行IVF与ICSI不同受精方式助孕的患者,其流产率、分娩率、抱婴儿回家率之间差异无统计学意义(P>0.05);流产组患者的年龄、胚胎种植率、多胎妊娠率及12天后的血β-HCG值均要低于分娩组,差异有统计学意义(P<0.05)。结论年龄及血β-HCG可早期预测IVF/ICSI的妊娠结局,对流产高风险患者及时进行保胎治疗,督促复诊,将有助于提高IVF/ICSI助孕后的活产率。
Objective To investigate the possible related factors of infertility patients receiving in vitro fertilization / intracytoplasmic sperm injection (IVF / ICSI) embryo transfer after clinical pregnancy. Methods 512 patients with clinical pregnancy who underwent IVF / ICSI in our hospital from January 2010 to December 2010 were divided into miscarriage group and delivery group according to pregnancy outcome. The methods of fertilization, age, etiology and 12 days after transplantation Blood β-HCG and other factors and the relationship between abortion rate. Results IVF / ICSI assisted pregnancy in patients with pregnancy, the abortion rate of 19.34%, with a rate of 37.31% of the baby to go home; line IVF and ICSI fertilization mode of pregnancy-assisted patients, the abortion rate, delivery rate, (P> 0.05). The age, embryo implantation rate, multiple pregnancy rate and β-HCG in 12 days after abortion group were all lower than those in labor group (P < 0.05). Conclusions Age and serum β-HCG can predict the pregnancy outcome of IVF / ICSI early and prompt misdiagnosis of miscarriage in patients with high risk of miscarriage, which will help increase the live birth rate after IVF / ICSI pregnancy.