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目的:探讨参芎葡萄糖注射液和5-氟尿嘧啶(5-Fu)联合治疗急性重症胰腺炎的临床疗效。方法:将45例急性重症胰腺炎的患者随机分为治疗组(22例)、对照组(23例),2组均采用一般治疗,治疗组使用参芎葡萄糖注射液100mL,静脉点滴,qd,连续7d,5-Fu250mg静脉点滴,qd,连续5d,对照组使用奥曲肽注射液0.1mg皮下注射,q8h,连续7d,观察临床疗效、住院时间、住院费用。结果:2组的治愈率、好转率、总有效率及平均住院日差异无显著性(P>0.05),治疗组的平均住院费明显低于对照组(P<0.05)。结论:参芎葡萄糖注射液和5-氟尿嘧啶联合治疗重症胰腺炎有较好的临床价值,可作为治疗急性重症胰腺炎的方法之一。
Objective: To investigate the clinical efficacy of Shenxiong glucose injection combined with 5-fluorouracil (5-Fu) in the treatment of acute severe pancreatitis. Methods: Forty-five patients with acute severe pancreatitis were randomly divided into treatment group (n = 22) and control group (n = 23). Two groups were treated with general treatment. The treatment group received 100 mL of Shenxiong glucose injection, intravenous drip, qd, Continuous 7d, 5-Fu250mg intravenous drip, qd, continuous 5d, the control group using 0.1mg octreotide injection 0.1mg subcutaneously, q8h, continuous 7d, observe the clinical efficacy, hospital stay, hospitalization costs. Results: There was no significant difference in the cure rate, improvement rate, total effective rate and average length of stay between the two groups (P> 0.05). The average hospitalization cost of the treatment group was significantly lower than that of the control group (P <0.05). Conclusion: Shenxiong glucose injection combined with 5-Fluorouracil has a good clinical value in the treatment of severe pancreatitis, which can be used as one of the methods to treat acute severe pancreatitis.