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癫痫是一种临床综合征,其特征为反复发作的大脑神经元异常放电所致的大脑功能失调,根据放电的部位和扩散的程度不同,临床表现为运动、感觉、意识、精神、自主神经等功能障碍,或兼而有之。流行病学调查显示:目前,全球约有6000万癫痫患者,癫痫人群的年发病率为50～70/10万,患病率约为3%～6%。癫痫的原因多样,按病因可将其分为原发和继发癫痫的发病机制复杂,主要是癫痫灶内突触功能的异常。即中枢神经系统兴奋与抑制不平衡,这主要与离子通道突触传递及神经胶质细胞的改变,神经内分泌功能的紊乱有关。无论继发或原发,其电生理改变是一致的,即表现为大脑神经元异常的过度性同步放电。在近10年有关癫痫的研究文献中,认为一氧化氮(NO)与癫痫关系密
Epilepsy is a clinical syndrome characterized by recurrent cerebral neuronal abnormalities caused by abnormal brain discharge, according to the different parts of the discharge and the degree of proliferation, clinical manifestations of movement, feeling, consciousness, spirit, autonomic nervous system, etc. Dysfunction, or both. Epidemiological survey shows that: At present, there are about 60 million epilepsy patients in the world. The annual incidence of epilepsy is 50-70 / 100,000 and the prevalence is about 3-6%. Epilepsy for various reasons, according to the etiology can be divided into primary and secondary epilepsy pathogenesis is complex, mainly in the epileptic foci synaptic abnormalities. That is excited and unbalanced central nervous system, which is mainly related to ion channel synaptic transmission and changes in glial cells, neuroendocrine disorders. Regardless of secondary or primary, its electrophysiological changes are consistent, that is, abnormal neurons in the brain excessive synchronic discharge. In the recent 10 years of research literature on epilepsy, that nitric oxide (NO) and epilepsy