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为观察滤过手术联合ａ干扰素，治疗难治性青光眼的疗效，将３４例（４２只眼）难治性青光眼随机分为ａＩＦ治疗组２２只眼与５ＦＵ对照组２０只眼。治疗组术中、术后，采用ａＩＦ球内（玻璃体内）或结膜下注射，对照组术后采用５ＦＵ结膜下注射。术后随访５～１４个月。结果ａＩＦ治疗组手术成功率为８１８％（１８／２２）５ＦＵ对照组为８５％（１７／２０），Ｐ＞００５。功能性滤过泡眼数，ａＩＦ治疗组为１７／２２，５ＦＵ对照组为１６／２０。治疗组未见明显全身和局部副作用。结论：ａＩＦ能促进滤过泡的形成，提高青光眼滤过手术的成功率，效果同５ＦＵ。
34 cases (42 eyes) refractory glaucoma were randomly divided into a IF treatment group 22 eyes and 5 FU control group 20 eye. Treatment group intraoperative and postoperative, using a IF intravitreous (vitreous) or subconjunctival injection, the control group after the use of 5 FU subconjunctival injection. The patients were followed up for 5 to 14 months. Results a IF treatment group was 81.8% (18/22) 5 FU control group was 85% (17/20), P> 0 05. The number of functional filter blisters, a IF treatment group was 17/22, 5 FU control group was 16/20. The treatment group showed no obvious systemic and local side effects. Conclusion: aIF can promote the formation of filtration bleb, improve the success rate of glaucoma filtration surgery, with the same effect 5FU.