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DNA甲基化和组蛋白甲基化是急性髓系白血病(AML)表观遗传学调控的常见模式。近年来,AML的DNA甲基化研究促进了针对DNA甲基化的治疗药物的发展,给AML的治疗提供了更多选择。去甲基化药物目前已广泛应用于临床,但在合理用药上仍然存在较多误区,除了选择合适的剂量和疗程外,治疗前明确甲基
DNA methylation and histone methylation are common patterns of epigenetic regulation of acute myeloid leukemia (AML). In recent years, AML DNA methylation research has promoted the development of DNA methylation-based therapies, providing more options for the treatment of AML. Demethylated drugs have been widely used in clinical practice, but there are still many errors in the rational use of drugs, in addition to select the appropriate dose and course of treatment, before treatment clear methyl