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目的探讨胃癌根治术后标本中葡萄糖转运蛋白-1(GLUT-1)与预后的关系。方法选取有完整术后病理及随访资料的胃癌根治术后患者215例,所有患者未接受术前新辅助放化疗,收集所有患者的临床、病理资料,采用免疫组化方法检测胃癌根治手术中GLUT-1的表达,COX多因素回归分析各因素对术后无病生存期(DFS)的影响,Kaplan-Meier方法绘制术后DFS曲线并计算中位DFS。结果胃癌组织中GLUT-1的表达水平与肿瘤的T分期相关。COX回归分析表明,GLUT-1的表达水平是影响术后胃癌患者DFS的独立预后因素(P<0.05)。GLUT-1表达水平低和高患者的术后中位DFS分别为69、63个月,Log-rank检验提示两组患者DFS曲线之间差异有统计学意义(P<0.01)。结论根治手术胃癌组织中GLUT-1的表达水平是影响DFS的独立不良预后因素。
Objective To investigate the relationship between the expression of glucose transporter 1 (GLUT-1) and the prognosis of gastric cancer after radical operation. Methods A total of 215 patients with radical gastrectomy after radical gastrectomy for gastric cancer were enrolled in this study. All patients were not receiving neoadjuvant chemoradiation and chemoradiotherapy. The clinical and pathological data of all patients were collected. Immunohistochemistry was used to detect the expression of GLUT -1, COX multivariate regression analysis of various factors on postoperative disease-free survival (DFS), Kaplan-Meier method to draw postoperative DFS curve and calculate the median DFS. Results The expression level of GLUT-1 in gastric cancer was correlated with the T stage of the tumor. COX regression analysis showed that the expression of GLUT-1 was an independent prognostic factor for postoperative DFS (P <0.05). The median postoperative DFS of patients with low and high GLUT-1 expression was 69 and 63 months, respectively. Log-rank test showed that the difference between the two groups was statistically significant (P <0.01). Conclusion The expression of GLUT-1 in radical surgery gastric cancer is an independent adverse prognostic factor affecting DFS.