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生长激素对肿瘤生长和荷瘤宿主代谢的作用机理尚不清楚。本研究意在确定重组生长激素(rGH)对原发性肿瘤生长、肿瘤转移和荷瘤动物体重的影响。 27只皮下植入PA-Ⅲ肿瘤(一种能自发地转移到肺和区域/远隔淋巴结的转移性前列腺腺癌)的雌性Lobund/wistar大鼠(重150～200g),给标准蛋白饮食(蛋白22.0％;4.20kcal/g)加libitum 28天,此时动物肿瘤体积达1.1～5.6cm~3。其后28～42天,动物随机接受标准蛋白饮食或等热量低蛋白饮食
The mechanism of action of growth hormone on tumor growth and tumor-bearing host metabolism remains unclear. This study was intended to determine the effect of recombinant growth hormone (rGH) on primary tumor growth, tumor metastasis, and weight of tumor-bearing animals. Twenty-seven female Lobund/wistar rats (weight 150–200 g) that were implanted subcutaneously with PA-III tumors (a metastatic prostate adenocarcinoma that spontaneously metastasized to the lungs and regions/distal lymph nodes) were given standard protein diets ( The protein was 22.0%; 4.20 kcal/g) plus libitum for 28 days. At this time, the animal tumor volume was 1.1-5.6 cm-3. After 28 to 42 days, the animals were randomly assigned to a standard protein diet or an isothermic low-protein diet