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目的:了解支气管哮喘患儿血清25羟维生素D水平，并分析其与总免疫球蛋白E(IgE)的关系。方法:选取泰州第四人民医院儿科2013年10月至2014年9月门诊或住院治疗的支气管哮喘患儿48例为哮喘组，以同期在儿童保健门诊体检的健康儿童35例为对照组，比较两组血清25羟维生素D及总IgE水平，采用Pearson相关性分析分析25羟维生素D与总IgE的关系。结果:哮喘组血清25羟维生素D为(35.86±14.31)nmol/L，明显低于对照组的(53.91±22.71)nmol/L，而IgE为(331.66±223.67)IU/mL，明显高于对照组的(99.33±86.50)IU/mL，差异均有统计学意义(n t＝4.32、2.36，均n P<0.05)；哮喘组患儿血清25羟维生素D与IgE呈负相关(n r＝－0.400，n P<0.05)。n 结论:支气管哮喘患儿25羟维生素D水平低于健康儿童，补充维生素D可能对预防和控制哮喘有一定的临床作用。“,”Objective:To measure the serum levels of 25-hydroxyvitamin D in children with asthma, and to investigate the relationship between the serum levels of 25-hydroxyvitamin D and total immunoglobulin E (TIgE).Methods:From October 2013 to September 2014, 48 children with bronchial asthma were selected as asthma group, and 35 healthy children were selected as control group.Double-antibody radioimmunoassay(RIA) was used to detect the levels of serum 25-hydroxyvitamin D and TIgE.Results:The serum level of 25-hydroxyvitamin D in the asthma group was (35.86±14.31)nmol/L, which was significantly lower than that in the control group[(53.91±22.71)nmol/L], and IgE level in the asthma group was (331.66±223.67)IU/mL, which was significantly higher than that in the control group [(99.33±86.50)IU/mL], the differences were statistically significant(n t=4.32, 2.36, all n P<0.05). There was a negative correlation between serum 25-hydroxyvitamin D and IgE in the asthma group(n r=-0.400, n P<0.05).n Conclusion:The serum levels of 25-hydroxyvitamin D may be associated with childhood asthma.The significant negative correlation between the levels of 25-hydroxyvitamin D and TIgE in children who had bronchial asthma indicates that asthma has a close relationship with allergy.Through increasing the concentration of 25-hydroxyvitamin D may prevent or treat child-hood asthma.