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微血管内皮异常或伴有高凝状态时,可导致血管内纤维蛋白沉积和微血栓形成。红细胞通过狭窄的管腔可遭受机械性损伤破坏而发生溶血,严重时可出现血红蛋白尿。主要的有关疾病如下。一、血栓性血小板减少性紫癜(TTP) 本病较少见,病因未明,可能与感染、药物和毒物的直接作用及免疫反应有关,亦有人认为此类患者血浆内缺乏内源性血小板聚集抑制因子—前列环素。
Microvascular endothelial dysfunction or hypercoagulable state can lead to intravascular fibrin deposition and microthrombus formation. Red blood cells through the narrow lumen can be damaged by mechanical damage and hemolysis, severe hemoglobinuria can occur. The main related diseases are as follows. First, the thrombotic thrombocytopenic purpura (TTP) The disease is rare, the etiology is unknown, may be related to infection, drugs and toxic effects and the direct effects of immune reaction, some people think that such patients lack of endogenous plasma platelet aggregation inhibition Factor - prostacyclin.