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目的··:探讨丁丙诺啡对阿片类药物依赖的治疗作用。方法··:以生理盐水为对照组 ,应用丁丙诺啡对吗啡依赖大鼠进行脱毒治疗 ,分别于停用吗啡24h,72h,8d观察其对湿狗样抖动、齿颤等戒断症状的影响及位置偏爱实验吗啡侧停留时间。结果··:丁丙诺啡能明显地缓解和控制戒断症状 ,递减顺利 ,但不能改变大鼠在吗啡侧停留时间。结论··:丁丙诺啡脱毒治疗没有明显改变依赖大鼠对阿片类药物的精神依赖 ,临床应用中加强心理治疗对预防复吸非常重要
Objectives: To investigate the therapeutic effect of buprenorphine on opioid dependence. Methods · · · ·: normal saline as a control group, the application of buprenorphine in morphine-dependent rats detoxification treatment, morphine withdrawal were observed at 24h, 72h, 8d observed wet dog-like jitter, toxoid and other withdrawal symptoms The influence and location preference of experimental morphine side dwell time. Results · · · ·: Buprenorphine significantly relieved and controlled withdrawal symptoms, decreasing smoothly, but failed to change the rat morphine side dwell time. Conclusion · · · ·: Buprenorphine detoxification treatment did not change significantly dependent on the psychological dependence of opioids in rats, clinical application of strengthening psychotherapy is very important to prevent relapse