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AIM:To evaluate the association between X-ray cross-complementing gene 1 (XRCC1) genetic polymorphismArg399GIn and gastric cancer risk by means of meta-analysis.METHODS:We searched PubMed and NCBI up toJune 1,2008.A total of 16 clinical trials and reportswere identified,but only 8 trials qualified under ourselection criteria.Statistical analysis was performedwith the software program Review Manage,version4.2.8.RESULTS:Of the 8 case-control studies selected forthis meta-analysis,a total of 1334 gastric cancer casesand 2194 controls were included.For Arg399GIn,theGin/Gin genotype carriers did not have a decreasedcancer risk compared with those individuals with theArg/Arg genotype (OR=0.92,95% CI,0.71-1.19;P=0.51).Similarly,no associations were found in therecessive and dominant modeling (Gin/Gin vs Arg/GIn+ Arg/Arg:OR=0.96; 95% CI,0.77-1.19; P=0.70and Gin/Gin + Arg/GIn vs Arg/Arg:OR=0.90,95%CI,0.77-1.05; P=0.18).CONCLUSION:No association is found between theXRCCl polymorphism Arg399GIn and gastric cancerrisk.