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自1963年Lewis和Szur首次报告急性骨髓纤维化(AMF)以来,国外陆续有文献报告。国内关于此病报告尚少。现将我们最近见到的一例报告如下。 张××,男,24岁。患者一月前始感乏力、头晕,并有中等度发热。外周血三系减少。骨穿示“骨髓增生极度低下”。1989年2月18日入院体检:T37.5℃,重度贫血貌。全身浅表淋巴结不大。胸骨无压痛,心肺正常。肝不大,脾肋下2.5cm,质中,无触痛。辅助检查:Hb42g/L,WBC3.1×10~9/L,N34/50,L12/50,Pt32×10~9/L,Ret0.2％。血片中偶见幼红幼粒细胞,部分成熟红细胞呈泪滴状。E SR 163mm/h,GPT42u,LDH234u,总蛋白60g/L,A/G=1/1,血清y—球蛋白占21.4％,
Since the first report of acute myelofibrosis (AMF) by Lewis and Szur in 1963, there are some reports in foreign countries. Domestic reports on the disease is still small. Here is a recent report we have seen. Zhang × ×, male, 24 years old. The patient felt weak, dizzy and had a moderate fever a month ago. Three-line reduction of peripheral blood. Bone wear “bone marrow hyperplasia extremely low.” February 18, 1989 admission examination: T37.5 ℃, severe anemia appearance. Systemic superficial lymph nodes is not large. Sternal no tenderness, normal heart and lungs. Liver is not large, spleen ribs 2.5cm, quality, no tenderness. Assisted examination: Hb42g / L, WBC3.1 × 10 ~ 9 / L, N34 / 50, L12 / 50, Pt32 × 10 ~ 9 / L, Ret0.2%. Occasionally young red blood cells in blood cells, some of the mature red blood cells were teardrop-shaped. E SR 163mm / h, GPT42u, LDH234u, total protein 60g / L, A / G = 1/1, serum y- globulin accounted for 21.4%