论文部分内容阅读
目的 :了解氧自由基在肾综合征出血热 (HFRS)病程中的血清变化规律 ,探索其在HFRS患者发病机制中的作用。方法 :对 96例HFRS患者的 12 1例次血清标本进行检测 ,动态观察血清超氧化物歧化酶 (SOD)及丙二醛 (MDA)在HFRS患者不同病期中的动态变化。结果 :发热期SOD的含量显著低于正常对照组 (P <0 0 1) ,MDA含量显著高于正常对照组 (P <0 0 1) ,在少尿期SOD、MDA的变化最为明显 (均为P <0 0 1) ,在该期中有并发症组SOD、MDA与无并发症组SOD、MDA相比均有显著差异 (分别为P <0 0 5、P <0 0 1) ,在多尿期和恢复期SOD、MDA逐渐趋于正常。结论 :自由基在HFRS各病期均有规律性异常变化 ,提示自由基可能参与了该病发病机制。该研究对进一步探讨HFRS的发病机制、研究临床相应的治疗、了解病情及判断预后有意义。
Objective: To investigate the changes of serum oxygen free radical during the course of hemorrhagic fever with renal syndrome (HFRS) and to explore its role in the pathogenesis of HFRS. Methods: A total of 121 serum samples from 96 patients with HFRS were detected. The dynamic changes of serum superoxide dismutase (SOD) and malondialdehyde (MDA) in different stages of HFRS were observed. Results: The content of SOD in the febrile stage was significantly lower than that in the normal control group (P <0.01), and the content of MDA was significantly higher than that in the normal control group (P <0.01) (P <0.01). There were significant differences in SOD and MDA between the complications group and the non-complications group during the period (P <0 05, P 0 01, respectively) Urine and recovery of SOD, MDA gradually became normal. Conclusion: There are regular changes of free radicals in each stage of HFRS, suggesting that free radicals may be involved in the pathogenesis of the disease. The study is further to explore the pathogenesis of HFRS, study the clinical treatment, to understand the condition and prognosis of meaningful.