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肝实质细胞和非实质细胞是肝脏功能的物质和结构基础.肝实质细胞是肝脏的主要细胞类型之一,承担和执行肝脏代谢、信号转导、解毒和稳态调节等多种功能.而非实质细胞也必不可少,主要包括星型细胞、肝窦内皮细胞、枯否细胞、自然杀伤细胞和隐窝细胞等,具有物质和信号转运、吞噬、抗原提呈、免疫耐受等功能.目前,有关肝脏生理功能和病理机制的研究主要集中在组织、细胞和差异分子的水平,单细胞的生理和病理功能研究也越来越深入,而肝脏细胞协作的研究比较少,系统性总结也鲜有报道.本文从肝脏细胞相互协作的角度,对肝脏的生理功能及病理机制进行探讨,为全面了解肝细胞生理功能及肝脏疾病的致病机理提供参考.
Liver parenchymal cells and non-parenchymal cells are the material and structural basis of liver function.Hepatocytes are one of the major cell types of the liver, which undertake and perform many functions such as liver metabolism, signal transduction, detoxification and homeostasis. Parenchymal cells are also essential, including astrocytes, sinusoidal endothelial cells, Kupffer cells, natural killer cells and crypt cells, with the material and signal transport, phagocytosis, antigen presentation, immune tolerance and other functions. , The researches on physiological function and pathological mechanism of liver mainly focus on the levels of tissues, cells and differential molecules. The research on the physiological and pathological functions of single cells is also more and more in-depth, and there are few researches on the cooperation of liver cells. It is reported that in this paper, the liver cells from the perspective of mutual cooperation, the physiological function of the liver and pathological mechanisms to explore in order to fully understand the physiological function of liver cells and pathogenic mechanisms of liver disease provide a reference.