Potassium dihydrogen phosphate catalyzed one-pot synthesis of 2,4,5-triaryl-1H-imidazoles

• 作 者: Ratnadeep S.Joshi Priyanka G.Mandhane Mohammad U.Shaikh Rajesh P.Kale Charansingh H.Gill
• 机 构: Department of Chemistry,Dr.Babasaheb Ambedkar Marathwada University,Aurangabad,Maharashtra 431 004,I
• 出 处: Chinese Chemical Letters
• 发表日期: 2010年04期
• 关键词: aldehyde imidazole afford condensation catalyzed ammonium potassium acetate subs

A simple and efficient method has been developed;benzil/benzoin undergoes smooth condensation with various substituted aldehyde and ammonium acetate in the presence of potassium dihydrogen phosphate(KH_2PO_4) under mild reaction conditions to afford the corresponding trisubstituted imidazole in excellent yields.The method for synthesis of product,the reaction mixture was reflux in ethanol for 40-90 min.The present method is simple,efficient,and cost-effective.

A simple and efficient method has been developed; benzil / benzoin undergoes smooth condensation with various substituted aldehydes and ammonium acetate in the presence of potassium dihydrogen phosphate (KH_2PO_4) under mild reaction conditions to afford the corresponding trisubstituted imidazole in excellent yields.The method for synthesis of product, the reaction mixture was reflux in ethanol for 40-90 min. The present method is simple, efficient, and cost-effective.