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冠心病合并非瓣膜性心房颤动患者支架植入术后需要抗血小板及口服抗凝药物治疗。抗血小板及抗凝治疗在减少缺血事件的同时也增加了出血风险。抗血小板药物与传统口服抗凝药物维生素K拮抗剂或新型口服抗凝药物如何联合使用以最大程度减少支架内血栓、系统性栓塞等缺血事件，同时又不显著增加出血事件，有待更多研究。“,”Patients with non-valvular atrial fibrillation undergoing percutaneous coronary intervention with drug-eluting stent implanta-tion need dual antiplatelet therapy as well as anticoagulation therapies.Dual antiplatelet therapy and anticoagulation therapy together can re-duce ischemic events, however, it can also increase bleeding events.More research is warranted to find an effective way to reduce ischemic events such as stent thrombosis and systemic embolism without increasing bleeding events through the combination of antiplatelet drugs with either vitamin K antagonist therapy or novel oral anticoagulants.