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目的探讨血清瘦素(1eptin)与原发性高血压的相互关系。评价瘦素在高血压发病中的作用。方法选择51例原发性高血压患者和30例健康体检者。分别检测受试者的身高、体重、血压、血脂、血糖及血清瘦素水平。结果高血压组瘦素水平显著高于对照组(P<0.01),空腹瘦素水平与体重指数(BMI)、血压均呈显著性相关(均为P<0.01)。结论血清leptin水平与高血压患者血压水平呈正相关,瘦素与肥胖型高血压的发病相关。
Objective To investigate the relationship between serum leptin (1eptin) and essential hypertension. Evaluation of leptin in the pathogenesis of hypertension. Methods 51 cases of essential hypertension and 30 healthy subjects were selected. Subjects were tested for height, weight, blood pressure, blood lipids, blood glucose and serum leptin levels. Results The level of leptin in hypertension group was significantly higher than that in control group (P <0.01). The level of fasting leptin was significantly correlated with body mass index (BMI) and blood pressure (all P <0.01). Conclusions Serum leptin level is positively correlated with the blood pressure level in hypertensive patients. Leptin is associated with the incidence of obesity-related hypertension.