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目的:观察中药辨证论治联合有创机械通气治疗老年性慢性阻塞性肺疾病的疗效。方法:60例老年性慢性阻塞性肺疾病伴机械通气治疗患者随机分成对照组(30例)和治疗组(30例),两组均给予西医抗感染、祛痰药、支气管扩张剂、有创机械通气治疗,治疗组加用中药灌服,所有患者均于治疗前及治疗后第7天检测TNF-α、IL-8、CRP、动脉血二氧化碳分压(PaCO2),并比较呼吸机相关性肺炎(VAP)发生率、机械通气时间,ICU住院时间。结果:治疗组的炎症因子TNF-α、IL-8、CRP较对照组明显好转(P<0.05),临床指标PaCO2、VAP发生率、机械通气时间及ICU住院时间等与对照组比较,差异均有统计学意义(P<0.05)。结论:中药灌服治疗较单纯西医治疗能明显改善老年性慢性阻塞性肺疾病患者的炎症因子,减少机械通气时间、VAP发生率及ICU住院时间,降低住院费用,且未见明显不良反应。
Objective: To observe the curative effect of syndrome differentiation of traditional Chinese medicine combined with invasive mechanical ventilation on senile chronic obstructive pulmonary disease. Methods: Sixty elderly patients with chronic obstructive pulmonary disease and mechanical ventilation were randomly divided into control group (30 cases) and treatment group (30 cases). Both groups were given anti-infective, expectorant, bronchodilator and invasive The patients in the treatment group and the treatment group were given traditional Chinese medicine. All the patients were tested for TNF-α, IL-8, CRP and PaCO2 before and 7 days after the treatment. The ventilator-related The incidence of pneumonia (VAP), duration of mechanical ventilation, length of hospital stay in ICU. Results: Compared with the control group, the levels of inflammatory cytokines TNF-α, IL-8 and CRP in the treatment group were significantly improved (P <0.05), and the clinical indicators PaCO2, VAP incidence, duration of mechanical ventilation and ICU hospital stay There was statistical significance (P <0.05). Conclusion: Compared with western medicine alone, traditional Chinese medicine can significantly improve the inflammatory cytokines, reduce the duration of mechanical ventilation, the incidence of VAP and ICU stay, reduce hospitalization costs, and no obvious adverse reactions.