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虽然在高血压性血管疾病中,血管紧张素Ⅱ(AngⅡ)可能参与了Rho激酶(ROCKs)的激活,但也不能排除血压本身的作用。高血压时,血管壁受到的机械应力增加,进而刺激血管平滑肌细胞增殖[91]。牵张诱导的ERK激活和血管平滑肌细胞增殖可以被ROCK抑制剂所抑制[92-93]。ROCK通路的另外一个
Although angiotensin II (Ang II) may be involved in the activation of Rho-kinase in hypertensive vascular disease, the role of blood pressure itself can not be ruled out. Hypertension increases the mechanical stress on the vascular wall, which in turn stimulates vascular smooth muscle cell proliferation [91]. Stretch-induced ERK activation and vascular smooth muscle cell proliferation can be inhibited by ROCK inhibitors [92-93]. Another ROCK access