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目的 :探讨妇女不育与巨细胞病毒 (HCMV)感染的关系。方法 :应用酶联免疫吸附试验 (ELISA)方法 ,对 98例育龄妇女的血清进行了巨细胞病毒抗体IgM、IgG的检测 ,其中 48例为不育妇女 ,另 5 0例为正常对照组。结果 :不育组HCMV_IgG的阳性率为 6 2 .5 % ,对照组为 70 .0 % ,两者差异不明显 (P >0 .0 5 ) ,但不育组HCMV_IgM阳性率为 48.5 % ,明显高于对照组的 4.0 % (P <0 .0 5 )。对不育组中习惯流产的患者进行清宫 ,组织送病检发现 :IgM阳性的患者其绒毛滋养层细胞明显增生 ,而合体细胞层无增生 ,蜕膜呈不同程度变性坏死 ,腺体高度分泌。结论 :巨细胞病毒感染可能与不育有关 ,对原因不明的不育妇女进行巨细胞病毒感染的检测有一定的临床意义。
Objective: To investigate the relationship between female infertility and cytomegalovirus (HCMV) infection. Methods: Serum samples of 98 women of childbearing age were tested for IgM and IgG by ELISA. Among them, 48 were infertile women and 50 were normal controls. Results: The positive rate of HCMV_IgG in infertility group was 62.5% and that in control group was 70.0%, but the difference was not significant (P> 0.05), but the positive rate of HCMV_IgM in infertility group was 48.5% Higher than 4.0% of the control group (P <0.05). Obstetrics and Gynecology group of patients with abortion of the Qing, the organization sent to the pathological examination found: IgM-positive patients with villous trophoblast cells were significantly hyperplasia, and the syncytial cell layer without proliferation, decidual degeneration and necrosis were varying degrees, a high degree of secretion of glands. Conclusion: Cytomegalovirus infection may be related to infertility. It is of clinical significance to detect cytomegalovirus infection in infertile women of unknown etiology.