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目的通过对新疆石河子地区孕中期孕妇唐氏综合征、爱德华兹综合征、神经管缺陷的风险状况分析,以期得到本地区筛查效率较高的孕周,为临床提供参考数据。方法用时间分辨法检测1799例孕中期15~20~(+6)w孕妇三联血清标志物浓度,运用专业的产筛软件进行胎儿风险评估,对比不同孕周筛查高风险、假阳性率和患儿检出率。结果孕中期产前筛查高风险主要集中在16-18w间,各孕周组间假阳性率无明显差异,孕周在16-18~(+6)w的检出率最高,为100%,筛查结果假阳性率最低,为5.18%。结论孕中期产前筛查最佳孕周段为16-18~(+6)w。
Objective To analyze the risk status of Down’s syndrome, Edwards syndrome and neural tube defects in the second trimester of pregnancy in Shihezi region of Xinjiang in order to get gestational weeks with high screening efficiency in this area and to provide reference data for clinical practice. Methods The concentrations of triple serum markers in 1799 pregnant women with 15 ~ 20 ~ (+6) w during pregnancy were detected by time-resolved method. The fetal risk assessment was performed by using specialized screen-producing software. The risk factors of screening for high risk, false positive rate and Children detection rate. Results The high risk of prenatal screening during the second trimester was mainly between 16 and 18 weeks. There was no significant difference in the false positive rates among the gestational age groups. The detection rate at 16-18 ~ (+6) w gestational weeks was the highest at 100% , The lowest false-positive screening rate was 5.18%. Conclusion The best prenatal screening for second trimester pregnancy is 16-18 ~ (+6) w.