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目的分析小剂量阿司匹林诱发胃溃疡的临床特征,指导临床诊治策略。方法回顾性分析136例小剂量阿司匹林诱发胃溃疡的临床资料,着重观察含不同PPI三联疗法的疗效,以及年龄、性别因素对疗效的影响。结果应用不同PPI的溃疡愈合率及HP根除率差异无统计学意义(P>0.05)。不同年龄段患者的溃疡治愈率差异无统计学意义(P>0.05),低年龄段HP根除率更高,差异具有统计学意义(P<0.05)。不同性别患者的溃疡治愈率及HP根除率差异无统计学意义(P>0.05)。结论对小剂量阿司匹林诱发的胃溃疡患者,在停用阿司匹林基础上,常规三联疗法能够有效治愈溃疡,不同PPI之间差异无统计学意义。高龄患者HP根除率更低,但其阳性率亦较低,所以是否需要再次根除HP需慎重评估利弊。
Objective To analyze the clinical characteristics of low-dose aspirin-induced gastric ulcer and guide clinical diagnosis and treatment strategies. Methods Retrospective analysis of 136 cases of low-dose aspirin-induced gastric ulcer clinical data, focusing on the efficacy of different PPI triple therapy, as well as age and gender factors on the effect. Results There was no significant difference in healing rate and HP eradication rate between different PPI groups (P> 0.05). There was no significant difference in the cure rate of ulcer among different age groups (P> 0.05). The HP eradication rate in lower age group was higher than that in the control group (P <0.05). There was no significant difference in cure rate and HP eradication rate between different sexes (P> 0.05). Conclusion Aspirin-induced gastric ulcer patients, based on the discontinuation of aspirin, conventional triple therapy can effectively cure the ulcer, the difference between the different PPI was not statistically significant. HP patients with lower eradication rates, but the positive rate is also low, so whether the need to re-eradicate HP should be carefully evaluated pros and cons.