Enrichment of AT-TA transversion at 5'-CAG-3' motif is not a unique mutational signature of

来源 :中国科学:生命科学英文版 | 被引量 : 0次 | 上传用户：yayagrace8

【摘要】

：

Aristolochic acids (AA) are the etiologic agents of aristolochic acid nephropathy (AAN) and contribute to the global prevalence of chronic kidney disease and ur

【作者】

：

Xin Wang Xinming Qi Jin Ren

【机构】

：

CenterforDrugSafetyEvaluationandResearch,UniversityofChineseAcademyofSciences

【出处】

：

中国科学:生命科学英文版

【发表日期】

：

2019年7期

【关键词】

：

Aristolochic ACIDS mutational SIGNATURE and hepatocellular carcinoma

【基金项目】

：

the National Science and Technology Major Project (2018ZX09101002-002).

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Aristolochic acids (AA) are the etiologic agents of aristolochic acid nephropathy (AAN) and contribute to the global prevalence of chronic kidney disease and urothelial cancer (Grollman et al.,2007).DNA adducts formed by AA generate a unique A>T transv

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Enrichment of AT-TA transversion at 5'-CAG-3' motif is not a unique mutational signature of

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