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用超滤方法从健康产妇胎盘中提取胎盘因子（PF），观察PF对四氯化碳（CCl4）引起的小鼠急性肝损伤的影响。结果发现ip或poPF15ml／（kg·d），连续7d，能明显抑制血清谷丙转氨酶的升高和肝脏脂质过氧化物的产生，减轻肝脏病理变化，增加肝脏还原型谷眈甘肽的含量。提示PF对小鼠CCl4肝损伤有保护作用，其作用机制可能与抑制脂质过氧化作用、提高肝细胞的抗氧化能力有关。
The placental factor (PF) was extracted from healthy maternal placenta by ultrafiltration and the effect of PF on acute liver injury induced by carbon tetrachloride (CCl4) in mice was observed. The results showed that ip or poPF15ml / (kg · d), for 7 days, can significantly inhibit the rise of serum alanine aminotransferase and liver lipid peroxidation, reduce liver pathological changes and increase the content of liver reduced glutathione . These results suggest that PF has a protective effect on liver injury induced by CCl4 in mice and its mechanism may be related to inhibition of lipid peroxidation and enhancement of antioxidant capacity of hepatocytes.