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目的:评估术前中性粒细胞／淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)、血小板／淋巴细胞比值( platelet to lymphocyte ratio,PLR)在非小细胞肺癌(non-small cell lung cancer,NSCLC)患者预后中的价值.方法:回顾性分析2012年1月至2014年4月在四川省肿瘤医院行根治性手术治疗的280例NSCLC患者的临床病理资料,根据受试者工作特征曲线(receiver operating characteristic curve,ROC)确定NLR、PLR的临界值,分析NLR、PLR与患者预后的相关性.结果:选取NLR=3. 25和PLR=122作为临界值.单因素分析显示TNM分期、T分期、N分期与无病生存期(disease-free survival,DFS)相关,P值分别为0. 001、0. 007、<0. 001;年龄、TNM分期、T分期、N分期、PLR与总生存期(overall survival,OS)相关,P值分别为0. 006、<0. 001、0. 035、<0. 001、<0. 001.多因素分析显示TNM分期(HR:1. 627,95% CI:1. 030~2. 568,P=0. 037)是影响DFS的独立危险因素.年龄( HR:1. 785,95% CI:1. 216~2. 622,P=0. 003)、TNM分期(HR:2. 094,95% CI:1. 231~3. 560,P=0. 006)、PLR(HR:1. 833,95% CI:1. 257~2. 674,P=0. 002)是影响OS的独立危险因素.结论:PLR或可作为评估经根治性手术治疗NSCLC患者预后的参考指标.“,”Objective: To evaluate the value of preoperative neutrophil to lymphocyte ratio (NLR) and platelet to lym-phocyte ratio (PLR) in predicting the prognosis of patients with non-small cell lung cancer. Methods: The clinicopathologic data of 280 NSCLC patients undergoing radical surgery from January 2012 to April 2014 in Sichuan Cancer Hospital were ret-rospectively analyzed according to the receiver operating characteristic curve (ROC). The critical values of NLR and PLR were determined. The correlation between NLR and the prognosis of patients and that between PLR and the prognosis of pa-tients was analyzed, respectively. Results:NLR=3. 25 and PLR=122 were selected as the critical values. Univariate analy- sis showed that TNM staging, T staging, and N staging were related to disease-free survival (DFS), and the P values were 0. 001, 0. 007, and less than 0. 001; age, TNM staging, T staging, N staging, and PLR were associated with overall sur-vival ( OS), P values were 0. 006, < 0. 001, 0. 035, <0. 001, <0. 001, respectively. Multivariate analysis showed that TNM staging ( HR: 1. 627, 95% CI: 1. 030~2. 568, P=0. 037) was an independent risk factor affecting DFS. Age (HR: 1. 785, 95% CI: 1. 216~2. 622, P=0. 003), TNM stage (HR: 2. 094, 95% CI: 1. 231~3. 560, P=0. 006) and PLR (HR: 1. 833, 95% CI: 1. 257~2. 674, P=0. 002) were independent risk factor affecting OS. Conclusion: PLR may be used as an indicator to evaluate the prognosis of patients undergoing radical surgery for NSCLC.