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目的分析178例氟喹诺酮类抗菌药物(FQNS)致药物不良反应及合理应用。方法选取2010年9月—2015年2月安平县人民医院收治的FQNS致药物不良反应患者178例,根据原卫生部药物不良反应筛选标准进行筛选,总结性别分布、年龄分布、药物名称、给药途径、症状表现。结果 178例FQNS致药物不良反应中左氧氟沙星79例(44.38%)、诺氟沙星66例(37.08%)、环丙沙星20(11.24%)、加替沙星7例(3.93%)、氧氟沙星6例(3.37%);主要累及神经系统,共52例(29.21%),临床表现为烦躁、头痛、焦虑、失眠等;静脉给药138例(77.53%),口服给药40例(22.47%);>60岁患者FQNS致药物不良反应发生率高于其他年龄段,差异有统计学意义(P<0.05)。结论 FQNS致药物不良反应较多,应严格按照规定的用法、用量使用,严格掌握适应证、禁忌证、慎用证,且不与其他药物联合应用,以促进临床合理用药,减少药物不良反应的发生。
Objective To analyze 178 cases of fluoroquinolone antibiotics (FQNS) caused by adverse drug reactions and rational use. Methods Seventy-eight patients with FQNS-induced adverse drug reactions admitted to Anping People’s Hospital from September 2010 to February 2015 were selected and screened according to the standards of drug adverse reaction screening of the Ministry of Health. The gender distribution, age distribution, drug name and administration Pathways, symptoms. Results 178 cases of FQNS induced adverse drug reactions in 79 cases (44.38%) of levofloxacin, norfloxacin 66 cases (37.08%), ciprofloxacin 20 (11.24%), gatifloxacin 7 cases (3.93% Freckle star in 6 cases (3.37%); mainly involving the nervous system, a total of 52 cases (29.21%), the clinical manifestations of irritability, headache, anxiety, insomnia; intravenous administration of 138 cases (77.53%), oral administration of 40 cases (22.47%). The incidence of FQNS-induced adverse drug reactions in patients> 60 years old was higher than that in other age groups (P <0.05). Conclusion FQNS caused many adverse drug reactions. It should be used in strict accordance with the prescribed usage and dosage. Strict indications, contraindications and caution should be used in combination with other drugs to promote rational clinical use and reduce adverse drug reactions occur.