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目的探讨二十味沉香丸对垂体后叶素诱导的大鼠心肌缺血的影响。方法给予大鼠舌下静脉iv垂体后叶素后,观察大鼠心电图T波、ST段的改变,测定左心室等容期压力最大变化速率、左心室舒张末压、左心室收缩压、平均动脉压和血清中乳酸脱氢酶(LDH)和肌酸激酶(CK)的活性。结果二十味沉香丸能显著改善心肌缺血大鼠ST段和T波的变化,增加心肌收缩力,降低血清中LDH和CK的活性,且呈剂量、时间依赖性。结论二十味沉香丸对垂体后叶素致大鼠心肌缺血损伤具保护作用。
Objective To investigate the effect of 20 flavor Shenxiang Pill on pituitrin-induced myocardial ischemia in rats. Methods After iv administration of vasopressin in sublingual vein of rats, the changes of T wave and ST segment of electrocardiogram were observed. The maximum rate of change of left ventricular pressure, left ventricular end diastolic pressure, left ventricular systolic pressure, mean arterial pressure Pressure and serum lactate dehydrogenase (LDH) and creatine kinase (CK) activity. Results Twenty taste incense pill can significantly improve the myocardial ischemia in ST segment and T wave changes, increase myocardial contractility, reduce serum LDH and CK activity, and in a dose-and time-dependent manner. Conclusion Twenty taste incense pills on pituitrin-induced myocardial ischemia injury in rats with a protective effect.