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混合性结缔组织病(MCTD)是1972年 Sharp等提出的。该病具有系统性红斑狼疮(SLE)、全身性硬皮病(PSS)、多发性皮肌炎(PMDM)的部分临床表现,抗核糖核蛋白(RNP)抗体升高。该症在小儿约有40%发生肾病变,本文报道1例合并重度肾病变的 MCTD。病例女、15岁。10岁发病,关节痛,雷诺征,发热伴颜面红斑,按 SLE 治疗。12岁时复发,抗 RNP 抗体阴性,肌张力低下,诊断 MCTD,接受
Mixed connective tissue disease (MCTD) was proposed by Sharp et al in 1972. The disease has partial clinical manifestations of systemic lupus erythematosus (SLE), systemic scleroderma (PSS), and multiple dermatitis (PMDM), and elevated anti-ribonucleoprotein (RNP) antibodies. The disease occurs in about 40% of children with nephropathy, reported in this paper, 1 case of severe nephropathy with MCTD. Female case, 15 years old. 10-year-old onset, joint pain, Renault sign, fever with facial erythema, according to SLE treatment. Recurrence at age 12, anti-RNP antibody negative, hypotonia, diagnosis of MCTD, accepted