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实体肿瘤的生成依赖于肿瘤本身新生血管的形成,肿瘤血管的再生受到众多血管刺激及抑制因子的调控。随着肿瘤血管再生理论和相应基础临床研究的快速进展,抗肿瘤血管生成治疗已成为肿瘤综合治疗中的一项重要内容。目前,已有多种血管生长抑制因子如血管抑素、肿瘤抑素等用于临床治疗研究,一些传统的抗血管生成药物也因此开辟了新的研究应用领域。现对血管生成(angiogenesis)在肿瘤发生发展中的作用、肿瘤治疗研究中的意义、抗肿瘤血管生成基因治疗研究中的进展作一综述。
The formation of solid tumors depends on the formation of neovascularization of the tumor itself. The regeneration of tumor blood vessels is regulated by numerous vascular stimuli and inhibitory factors. With the rapid development of tumor angiogenesis theory and the corresponding basic clinical research, anti-angiogenesis therapy has become an important part in the comprehensive treatment of cancer. At present, a variety of angiogenesis inhibitors such as angiostatin and somatostatin have been used in clinical research, and some traditional antiangiogenic drugs have opened up new research and application fields. Now the role of angiogenesis in the development of tumors, the significance of tumor therapy research, and the progress in anti-tumor angiogenesis gene therapy research.