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目的探讨高压氧联合醒脑静注射液治疗重型颅脑外伤的临床疗效。方法选取重型颅脑外伤患者135例,随机分为A组、B组和C组,每组各45例,A组采用高压氧联合醒脑静注射液治疗,B组仅采用醒脑静注射液治疗,C组仅采用高压氧治疗,比较三组患者的治疗效果。结果三组患者治疗后的意识清醒和日常生活能力均较治疗前有所提高,且A组患者提高幅度最大,与B组、C组患者比较有统计学差异(P<0.05)。A组、B组、C组治疗有效率分别为88.9%、71.1%、68.9%,A组与B组、C组治疗有效率比较有统计学差异(P<0.05);不良事件发生率分别为11.1%、8.9%、6.7%,三组间比较无统计学差异(P>0.05)。结论采用高压氧联合醒脑静注射液治疗重型颅脑外伤可提高疗效,不良事件发生率与单一使用高压氧或醒脑静注射者无明显差异。
Objective To investigate the clinical effects of hyperbaric oxygen combined with xingnaojing injection in treating severe traumatic brain injury. Methods 135 cases of severe traumatic brain injury were randomly divided into A group, B group and C group, 45 cases in each group. A group was treated with hyperbaric oxygen combined with Xingnaojing injection. B group was treated with Xingnaojing injection Treatment, C group only hyperbaric oxygen therapy, the treatment effect of three groups of patients were compared. Results After treatment, the consciousness and daily living ability of the three groups of patients were better than those before treatment. The patients in group A had the highest increase rate compared with those in group B and C (P <0.05). The effective rates of treatment in group A, group B and group C were 88.9%, 71.1% and 68.9%, respectively, and there was significant difference between group A and group B and group C (P <0.05). The incidence of adverse events were 11.1%, 8.9% and 6.7% respectively. There was no significant difference among the three groups (P> 0.05). Conclusion Hyperbaric oxygen combined with xingnaojing injection in the treatment of severe craniocerebral trauma can improve the curative effect, the incidence of adverse events and single use of hyperbaric oxygen or Xingnaojing injection were no significant differences.