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目的探讨血尿酸与代谢综合征(metabolic syndrom e,MS)各组分之间的相关性及相关程度。方法选取2010年在本院参加体检的主城区居民79 092例,年龄18～95岁,其中男性45 495例,女性33 597例,测定血尿酸、体质量指数、腰围、收缩压、舒张压、空腹血糖、总胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇等水平,分析血尿酸与各指标的相关性。结果男性高尿酸血症患病率明显高于女性(男性22.19%,女性6.05%,P<0.01);男女组的体质量指数、腹围、收缩压、舒张压、总胆固醇、甘油三酯、低密度脂蛋白胆固醇与血尿酸水平呈正相关(P<0.05),而与高密度脂蛋白胆固醇则呈负相关(P<0.01);血尿酸水平与MS患病风险性密切相关。无论男女,随着血尿酸水平的升高,MS患病率逐渐增加。结论血尿酸水平与MS密切相关,控制血尿酸水平是预防M S的发生及降低心血管事件风险的重要环节之一。
Objective To investigate the correlation between serum uric acid and metabolic syndrom e (MS) components. Methods A total of 79 092 residents aged from 18 to 95 years were enrolled in this study. Among them, 45 495 males and 33 597 females were enrolled in this study. Serum uric acid, body mass index, waist circumference, systolic blood pressure, diastolic blood pressure, Fasting blood glucose, total cholesterol, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and other levels of serum uric acid and the correlation between the indicators. Results The prevalence of hyperuricemia in males was significantly higher than that in females (22.19% in males and 6.05% in females, P <0.01). The body mass index, abdominal circumference, systolic blood pressure, diastolic blood pressure, total cholesterol, triglycerides, Low density lipoprotein cholesterol was positively correlated with serum uric acid (P <0.05), but negatively correlated with high density lipoprotein cholesterol (P <0.01). Serum uric acid level was closely related to the risk of MS. Both men and women, with the rise of serum uric acid levels, MS prevalence increased. Conclusion Serum uric acid level is closely related to MS. Control of serum uric acid level is one of the important links to prevent the occurrence of M S and reduce the risk of cardiovascular events.