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目的探讨参灵扶正胶囊联合高效抗逆转录病毒疗法(HAART)治疗艾滋病病毒(HIV)感染者或艾滋病(AIDS)患者的临床疗效。方法将60例HIV/AIDS患者随机分为治疗组和对照组各30例,治疗组给予参灵扶正胶囊及HAART,对照组给予HAART,两组均治疗6个月,观察两组临床疗效、常见毒副反应发生情况、生存质量积分及其他不良反应。结果治疗组有效30例,对照组有效29例,两组比较差异无统计学意义(P>0.05)。治疗组治疗后生存质量积分中生理领域、心理领域、独立性领域、总体健康状况和总体生存质量评分均较治疗前明显提高(P<0.05);对照组治疗后独立性领域、总体健康状况和总体生存质量评分与治疗前比较明显提高(P<0.05);治疗后生理领域、心理领域、总体健康状况和总体生存质量评分治疗组均高于对照组(P<0.05)。治疗后治疗组患者出现了恶心(或呕吐)、头痛、疲乏、眩晕、腹泻、腹胀、肝功能异常和骨髓抑制;对照组患者出现了恶心(或呕吐)、疲乏、眩晕、腹泻、腹胀、皮疹、肝功能异常和骨髓抑制,治疗组恶心(或呕吐)、疲乏发生率与对照组比较差异有统计学意义(P<0.05)。结论参灵扶正胶囊联合HAART治疗HIV/AIDS患者,能够提高患者生存质量,减少恶心(或呕吐)、疲乏等毒副反应的发生。
Objective To investigate the clinical efficacy of Shenling Fuzheng Capsule combined with Highly Active Anti-retroviral Therapy (HAART) in the treatment of HIV-infected or AIDS patients. Methods Sixty HIV / AIDS patients were randomly divided into treatment group (30 cases) and control group (30 cases). The treatment group was given Shenling Fuzheng Capsule and HAART. The control group was given HAART. Both groups were treated for 6 months. The clinical efficacy, common Toxic reactions, quality of life points and other adverse reactions. Results The treatment group, effective in 30 cases, 29 cases in the control group, no significant difference between the two groups (P> 0.05). The score of physical quality, psychology, independence, general health and overall quality of life in the treatment group after treatment were significantly higher than those before treatment (P <0.05). The scores of independence, overall health and The overall quality of life score was significantly higher than that before treatment (P <0.05). After treatment, the scores of physiological field, psychological field, general state of health and total quality of life in the treatment group were higher than those in the control group (P <0.05). Nausea (vomiting), headache, fatigue, dizziness, diarrhea, bloating, abnormal liver function, and bone marrow suppression occurred in the treatment group in the treatment group. Nausea (or vomiting), fatigue, dizziness, diarrhea, bloating, , Liver dysfunction and myelosuppression. The incidence of nausea (or vomiting) and fatigue in the treatment group was significantly different from that in the control group (P <0.05). Conclusion Shenling Fuzheng Capsule combined with HAART in the treatment of HIV / AIDS patients can improve the quality of life of patients and reduce the occurrence of nausea (or vomiting) and fatigue.