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目的 探讨蛛网膜下腔出血 (SAH)后血及脑脊液 (CSF)中纤溶活性的变化规律。方法 应用酶联免疫吸附试验 (EL ISA)双抗体夹心法检测 SAH患者发病后 0～ 3天 (急性期 )、4～ 9天 (再出血高峰期 )及 14～ 2 1天 (吸收期 )血及 CSF中 D-二聚体 (D- D)含量 ,并与正常对照组比较。结果 SAH后血及 CSF中 D- D水平显著增高 ,但随时间延长而显著降低 ,0～ 3天及 4～ 9天显著高于对照组 ,14～ 2 1天与对照组无差异性 ;0～ 3天 CSF中 D- D水平显著高于血液中 D- D水平。结论 SAH后血及 CSF中纤溶活性急性期显著升高 ,随病程延长而迅速降低 ;急性期 CSF中纤溶活性升高比血液中更明显
Objective To investigate the changes of fibrinolytic activity in blood and cerebrospinal fluid (CSF) after subarachnoid hemorrhage (SAH). Methods Serum samples were collected from patients with SAH at 0-3 days (acute phase), 4-9 days (peak of rebleeding) and 14-21 days (absorption phase) by enzyme linked immunosorbent assay (ELISA) And D-dimer (D-D) in CSF, and compared with the normal control group. Results The level of D-D in blood and CSF was significantly increased after SAH, but decreased significantly with time. The levels of D-D in blood and CSF were significantly higher at 0-3 days and 4-9 days than those in control group. There was no difference between control group and 14-21 days The level of D-D in the CSF at 3 days was significantly higher than the level of D-D in the blood. Conclusions The acute phase of fibrinolytic activity in blood and CSF is significantly increased after SAH, and decreases rapidly with the prolongation of the course of SAH. The increase of fibrinolytic activity in acute CSF is more obvious than that in blood