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目的：探讨肿瘤治疗中３２磷玻璃微球间质治疗联合加热治疗的作用及作用机制。方法：以小鼠Ｓ１８０瘤株接种ＩＣＲ小鼠造成实体瘤动物模型，给予３２磷玻璃微球（３２Ｐ－ＧＭＳ）间质治疗，并联合加热治疗，透射电镜下观察肿瘤细胞的形态学变化。结果：３２Ｐ－ＧＭＳ间质治疗组核膜等质膜损伤显著；加热治疗组溶酶体明显增多；联合治疗组两种变化兼有。结论：实验结果支持核膜是射线作用的靶的理论，并提示溶酶体在热损伤中可能起重要作用
Objective: To investigate the role and mechanism of combined heat treatment of interstitial therapy with 32-phosphate microspheres in tumor therapy. METHODS: The animal model of solid tumor was induced by inoculating ICR mouse with S180 tumor strain. The 32-phospho-glass microspheres (32P-GMS) were used for interstitial therapy. Combined with heating treatment, the morphological changes of tumor cells were observed under transmission electron microscope. RESULTS: In the 32P-GMS interstitial treatment group, the nuclear membrane and plasma membrane were significantly damaged; the lysosomes in the heated treatment group were significantly increased; both of the combined treatment groups had both changes. Conclusion: The experimental results support the theory that the nuclear membrane is the target of ray action and suggest that lysosomes may play an important role in thermal injury.