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虽然目前丙戊酸已在世界范围得到临床应用,然该药抗惊厥作用的机理尚未确定。从动物研究中得出的假说是:丙戊酸增高脑的抑制性神经介质r-氨基丁酸(GABA)的水平。大剂量丙戊酸(≥200mg/kg)用于啮齿动物,可导致脑内GABA显著增高,其与该药的抗惊厥活性密切相关。虽然已报导丙戊酸显著增高血浆GABA水平,然而在癫痫患者中未证实丙戊酸能增高中枢GABA水平。丙戊酸导致狗的脑GABA增高,同样反映在脑脊液GABA水平的相应
Although valproic acid has been clinically applied worldwide, the mechanism of anticonvulsant effect of this drug has not yet been established. The hypothesis drawn from animal studies is that valproic acid increases the levels of brain-inhibitory neurotransmitter r-aminobutyric acid (GABA). High doses of valproic acid (≥ 200 mg / kg) for rodents can cause a significant increase in brain GABA, which is closely related to the anticonvulsant activity of the drug. Although valproate has been reported to significantly increase plasma GABA levels, valproic acid has not been demonstrated to increase central GABA levels in epileptic patients. Valproic acid causes increased brain GABA in dogs, which is also reflected in the level of cerebrospinal fluid GABA