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目的探讨早期集束化在感染性休克治疗中的应用价值。方法 120例感染性休克患者,随机分为对照组和观察组,各60例。对照组患者采取常规治疗方案,观察组施行早期集束化治疗。对比两组患者抗生素应用时间、多器官功能障碍综合征(MODS)发生率、住院时间、病死率及各项指标的变化。结果观察组患者抗生素使用时间(1.52±0.89)d短于对照组(4.34±2.56)d(P<0.05)。观察组呼吸机使用(8.91±5.17)d短于对照组(13.15±6.48)d(P<0.05)。观察组患者ICU住院时间(9.27±6.19)d短于对照组住ICU时间(14.06±9.55)d(P<0.05)。对照组MODS发生率为61.7%(37/60),显著高于观察组的25.0%(15/60)(P<0.05)。观察组住院期间死亡率21.67%(13/60)短于对照组的48.3%(29/60)(P<0.05)。结论早期集束化治疗感染性休克效果值得肯定,能够促进机体恢复,减少并发症发生,降低死亡率。
Objective To explore the value of early bundling in the treatment of septic shock. Methods A total of 120 septic shock patients were randomly divided into control group and observation group, with 60 cases in each group. The control group patients to take conventional treatment programs, the observation group administered early bundling therapy. Antibiotic application time, incidence of multiple organ dysfunction syndrome (MODS), length of hospital stay, fatality rate and changes of each index were compared between the two groups. Results The duration of antibiotic use in the observation group was shorter than that in the control group (1.52 ± 0.89 days vs 4.34 ± 2.56 days, P <0.05). The use of ventilator in the observation group (8.91 ± 5.17) d was shorter than that in the control group (13.15 ± 6.48) d (P <0.05). The hospital stay of ICU in observation group (9.27 ± 6.19) d was shorter than that in control group (14.06 ± 9.55) d (P <0.05). The incidence of MODS in the control group was 61.7% (37/60), significantly higher than that in the observation group (25.0%, 15/60) (P <0.05). The mortality rate in observation group was shorter than that in control group (21.67%, 13/60) (48.3%, 29/60) (P <0.05). Conclusions Earlier bundling treatment of septic shock was worthy of recognition, which could promote the recovery of the body, reduce the incidence of complications and reduce the mortality rate.