论文部分内容阅读
目的：研究萘普生β－环糊精（Ｎａｐ·βＣＤ）包合物的抗炎镇痛效果。方法：取大鼠或小鼠随机分成对照组和实验组，采用足跖肿胀法、扭体反应法和电刺激痛阈值法测定。结果：Ｎａｐ与Ｎａｐ·β－ＣＤ包合物测定值ｔ检验，给药后３０ｍｉｎ小鼠扭体值：２５．０ｍｇ／ｋｇ组Ｐ＜００５，１２．５ｍｇ／ｋｇ组Ｐ＜００５；大鼠痛阈值（给药１５ｈ）：２５．０ｍｇ／ｋｇ组Ｐ＜００５，１２．５ｍｇ／ｋｇ组Ｐ＞００５；大鼠足跖肿胀率（给药１ｈ）：Ｐ＜００１．结论：Ｎａｐ·β－ＣＤ包合物的抗炎镇痛作用优于Ｎａｐ单体。
Objective: To study the anti-inflammatory and analgesic effect of naproxen β-cyclodextrin (Nap · βCD) inclusion complex. Methods: Rats or mice were randomly divided into control group and experimental group. The soles were swollen, writhing and electrical stimulation of pain threshold. Results: Nap and Nap β-CD inclusion complex t-test values, 30min after administration of the mouse writhing value: 25.0mg / kg group P <0 05, 12.5mg / kg group P <0 05 ; Rat pain threshold (administration 1 5h): 25.0mg / kg group P <0 05,12.5 mg / kg group P> 0 05; rat paw edema rate (administration 1h): P <0 01. Conclusion: The anti-inflammatory and analgesic effect of Nap · β-CD inclusion compound is better than Nap monomer.