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目的从文献计量学角度分析并了解多黏菌素耐药革兰阴性菌的耐药机制和耐药现状。方法检索Pub Med、Em Base、Web of Science、中国知网、万方数据库中的相关文献,用Endnote X7软件去重、筛选,对纳入文献的外部特征及研究内容进行归纳及分析。结果共纳入外文文献374篇、中文文献174篇。耐药率为0.1%~31.0%;耐药机制多为染色体介导,以外膜脂多糖修饰或丢失为主;2015年中国学者首次报道了质粒介导的新型耐药基因mcr-1。结论革兰阴性菌对多黏菌素耐药率增长。
Objective To analyze and understand the drug resistance mechanism and drug resistance status of multi-gram drug-resistant gram-negative bacteria from the perspective of biodometrics. Methods We searched PubMed, Em Base, Web of Science, CNKI and Wanfang database for deduction and screening with Endnote X7 software, and summarized and analyzed the external characteristics and contents of the included articles. Results A total of 374 foreign literature and 174 Chinese literature were included. The drug resistance rates ranged from 0.1% to 31.0%. The mechanism of drug resistance was mostly chromosome-mediated, with modification or loss of outer lipopolysaccharide. In 2015, Chinese scientists first reported the plasmid-mediated resistance gene mcr-1. Conclusion Gram-negative bacteria increased the rate of resistance to polymyxin.