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凝血酶能催化纤维蛋白原转变成纤维蛋白,也能诱导血小板粘附、聚集和释放等反应,是血小板的强诱导剂,因而在血液凝固、血栓形成中起重要作用.近年来,人们对凝血酶的结构和功能进行了广泛深入的研究,除了确定了凝血酶分子中的催化部位外,还发现凝血酶分子中有蛋白质结合/识别区域、载脂蛋白结合区域、趋化作用区域等,从而对凝血酶的功能又有了新的认识. 一、凝血酶的激素样效应α-凝血酶除了是蛋白水解酶外,也是一种
Thrombin can catalyze the conversion of fibrinogen to fibrin, also can induce the platelet adhesion, aggregation and release reactions, is a strong inducer of platelets, and therefore plays an important role in blood coagulation, thrombosis .In recent years, people on the coagulation Enzyme structure and function of a wide range of in-depth study, in addition to determine the catalytic site of thrombin molecules, but also found in the thrombin molecule protein binding / recognition region, apolipoprotein binding region, chemotaxis region, and so on A new understanding of the function of thrombin, a, thrombin hormone-like effect α-thrombin in addition to proteolytic enzymes, but also a