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目的:考察谷氨酰胺对焦虑和抑郁情绪致妇科肿瘤患者细胞免疫功能低下的影响。方法:取2010年8月~2014年1月收治的妇科肿瘤患者139例,按数字随机法将患者随机分为2个组,68例对照组和71例观察组,两组患者均接受择期肿瘤切除术,术后当天至1周内给予常规肠道营养支持。观察组在常规治疗的基础上加用丙氨酰谷氨酰胺(哈尔滨药业有限公司)0.3~0.4 g·kg-1·d-1,持续治疗1个月。结果:两个组别术前和术后焦虑自评量表(SAS)、汉密尔顿抑郁自评量表(HAMD)及T淋巴细胞亚群无统计学差异(P>0.05),术后治疗1个月,两个组别SAS、HAMD均有改善,CD3+、CD4+和CD4+/CD8+均升高,与对照组比,观察组SAS、HAMD改善明显,CD3+、CD4+和CD4+/CD8+升高显著。结论:采用谷氨酰胺可直接改善妇科肿瘤患者焦虑和抑郁症状,也可以通过提高细胞免疫功能达到改善妇科肿瘤患者焦虑和抑郁症状的目的。
Objective: To investigate the effect of glutamine on cellular immunity in gynecologic oncology patients with anxiety and depression. Methods: One hundred and ninety-nine patients with gynecologic cancer who were admitted from August 2010 to January 2014 were randomly divided into two groups according to the random number method, 68 patients in the control group and 71 patients in the observation group. Both patients underwent elective cancer Excision, postoperative day to 1 week to give regular intestinal nutrition support. The observation group was treated with 0.3 ~ 0.4 g · kg-1 · d-1 alanylglutamine (Harbin Pharmaceutical Co., Ltd.) on the basis of routine treatment for 1 month. Results: There was no significant difference between the two groups in preoperative and postoperative anxiety scale (SAS), Hamilton Depression Scale (HAMD) and T lymphocyte subsets (P> 0.05), postoperative treatment 1 Month. SAS and HAMD were improved in both groups. CD3 +, CD4 + and CD4 + / CD8 + were increased in both groups. Compared with the control group, the SAS and HAMD scores in the observation group were significantly improved and the levels of CD3 +, CD4 + and CD4 + / CD8 + increased significantly. Conclusion: The use of glutamine can directly improve the symptoms of anxiety and depression in patients with gynecologic cancer, and can also improve anxiety and depression symptoms of gynecologic cancer patients by improving cellular immune function.