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目的:研究再生基因4(RegIV)和趋化因子CCL7在胃癌中的表达及相关性。方法:选择2010年3月至2014年3月在我院接受手术治疗的胃癌患者72例作为研究对象。对比RegIV及CCL7在胃癌组织以及癌旁正常组织中的阳性表达情况,分析不同病理参数对RegIV及CCL7阳性表达的影响,RegIV与CCL7表达的相关性及影响RegIV及CCL7在胃癌中表达的危险因素。结果:胃癌组织的RegIV阳性率及CCL7阳性率均显著高于癌旁正常组织,差异均有统计学意义(均P<0.05)。有浆膜浸润、有淋巴结转移以及TNM分期为Ⅲ~Ⅳ期者的RegIV与CCL7阳性表达率均显著高于无浆膜浸润、无淋巴结转移以及TNM分期为0~Ⅱ期者,差异均有统计学意义(均P<0.05)。经Spearman法分析相关性可知,RegIV与CCL7表达呈正相关。根据Logistic回归分析法可知,有浆膜浸润、有淋巴结转移以及TNM分期为Ⅲ~Ⅳ期均为RegIV及CCL7在胃癌中表达的危险因素。结论:RegIV与CCL7均可在胃癌组织中呈现出较高的阳性表达,且二者与患者临床预后有密切关系,在临床治疗过程中值得关注与重视。
Objective: To study the expression and correlation of RegIV and CCL7 in gastric cancer. Methods: Seventy-two patients with gastric cancer undergoing surgery in our hospital from March 2010 to March 2014 were selected as the study subjects. To compare the positive expression of RegIV and CCL7 in gastric cancer tissues and adjacent normal tissues, analyze the influence of different pathological parameters on the expression of RegIV and CCL7, the correlation between RegIV and CCL7 expression and the risk factors of RegIV and CCL7 expression in gastric cancer . Results: The positive rate of RegIV and the positive rate of CCL7 in gastric cancer tissues were significantly higher than those in adjacent normal tissues (all P <0.05). The positive rates of RegIV and CCL7 in patients with serosal invasion, lymph node metastasis and TNM stage Ⅲ ~ Ⅳ were significantly higher than those without serosal invasion, lymph node metastasis and TNM stage 0 ~ Ⅱ Significance (both P <0.05). Spearman analysis of the correlation shows that, RegIV and CCL7 expression was positively correlated. According to Logistic regression analysis, it was found that serosal invasion, lymph node metastasis and TNM stage Ⅲ ~ Ⅳ were the risk factors of RegIV and CCL7 expression in gastric cancer. Conclusions: Both RegIV and CCL7 are highly expressed in gastric cancer tissues. Both of them are closely related to the clinical prognosis of patients and deserve attention and attention in the course of clinical treatment.