论文部分内容阅读
PA（PksmlnosenActivator）是体内一重要蛋白水解酶系统．包括tPA和uPA二型，主要水解纤溶酶原为纤溶酶，从而启动对多种细胞外基质蛋白的水解，同时还可直接裂解纤粘素、胶原酶IV和肝细胞生长因子等。PA的抑制剂PAI（PlasminogenActivatorlrl－hibitor）包括PAI-1和PAI-2两种，二者均抑制tPAuPA。PAI－1合成于角既细胞（kerationcvtKC）和其他多种细胞分布较广。PAI—2合成于角朊细胞和巨噬细胞，主要见于表皮，在妊娠期胎盘和血浆中含量明显增高。作者对tPA／PAI－2的研究工作发现，在分化中，角朊细胞产生tPA，后者破坏细胞与细胞之间的连接，介导粒层细胞中大块蛋白降解，产生一些具有化学趋化性的蛋白水解片断，核崩解；tPA还可帮助角阮细胞成层排列，并分离上皮表面已终未分化的鳞片。？＊1－2则主要合成于基底上层角既细胞，沿细胞周围分布并和细胞外基质蛋白结合，调控表皮分化中tPA的复杂水解过程。最近我们发现，tPA信号仅出现在毛囊下段的基质细胞中，并选择性的表达在某特定的毛发周期中。由上可见，tPA／PAI－2系统的研究对阐明表皮细胞分化及其调控机理、细胞粘附、游走等重大理论课题有很重要的意义，对组织损伤修复过程和某些表应分化不全疾病（如牛皮癣）的病因研究等课题也有重要价值
PA (PksmlnosenActivator) is an important proteolytic enzyme system in vivo. Including tPA and uPA type II, the main hydrolysis of plasminogen plasmin, thus initiating a variety of extracellular matrix protein hydrolysis, but also direct cleavage of fibronectin, collagenase IV and hepatocyte growth factor. The PA inhibitor PAI (Plasminogen Activatorlrl-hibitor) includes both PAI-1 and PAI-2, both of which inhibit tPAuPA. PAI-1 synthesis in the angular cells (kerationcvtKC) and a wide range of other cells. PAI-2 is synthesized in keratinocytes and macrophages, mainly in the epidermis, and is significantly increased in placenta and plasma during pregnancy. The authors of the study of tPA / PAI-2 found that during differentiation, keratinocytes produce tPA, which disrupts cell-cell connections and mediates the degradation of large proteins in granulosa cells, resulting in chemotaxis Sex proteolytic fragments, nuclear disintegration; tPA can also help the angular Nguyen cells layered arrangement, and the separation of epithelial surface has not been undifferentiated scales. ? * 1-2 is mainly synthesized in the upper corner of the base of both cells, distributed along the cell periphery and the combination of extracellular matrix proteins, regulating epidermal differentiation in the complex hydrolysis of tPA. Recently, we found that tPA signaling occurs only in stromal cells in the lower follicles and is selectively expressed in a particular hair cycle. It can be seen from the above that the study of tPA / PAI-2 system is of great significance to elucidate the major theoretical topics such as epidermal cell differentiation and its regulation mechanism, cell adhesion and migration. It is of great significance to the tissue damage repair process and some tables should be poorly differentiated Diseases (such as psoriasis) etiology research topics also have important value