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目的探讨肺炎衣原体(Chlamydia pneumoniae)感染在多发性硬化(MS)发病和进展中的作用和致病机制。方法选取急性期MS患者31例,缓解期MS患者28例及其他神经系统疾病患者30例,健康对照者30名,应用酶联免疫吸附试验测定患者和对照者血清及脑脊液中肺炎衣原体IgG和IgM抗体水平。结果急性期MS组、缓解期MS组、其他神经系统疾病组和健康对照组的肺炎衣原体血清IgG分别为48.4%、35.7%、30.0%、23.3%;4组IgM抗体效价分别为12.9%、14.3%、20.0%、10.0%,总体比较差异无统计学意义(P>0.05);急性期MS组与其他神经系统疾病组的脑脊液IgG和IgM抗体效价分别为0、6.7%和0、0,差异无统计学意义(P>0.05)。结论肺炎衣原体的感染或重复感染与MS发病相关不紧密,可能仅为MS的伴随感染。
Objective To investigate the role and pathogenesis of Chlamydia pneumoniae infection in the pathogenesis and progression of multiple sclerosis (MS). Methods 31 patients with acute MS, 28 MS patients with remission, 30 patients with other neurological diseases and 30 healthy controls were enrolled in this study. Serum and CSF Chlamydia pneumoniae IgG and IgM were measured by enzyme-linked immunosorbent assay Antibody level. Results Serum IgG levels of Chlamydia pneumoniae were 48.4%, 35.7%, 30.0% and 23.3% respectively in acute MS group, remission MS group, other neurological diseases group and healthy control group. The titer of IgM antibody in 4 groups was 12.9% 14.3%, 20.0% and 10.0%, respectively. There was no significant difference between the two groups (P> 0.05). The antibody titer of IgG and IgM in cerebrospinal fluid in MS group and other neurological disease groups were 0, 6.7% and 0,0 , The difference was not statistically significant (P> 0.05). Conclusion The infection or repeated infection of Chlamydia pneumoniae is not closely related to the onset of MS, which may be only the companion infection of MS.